Endocrine Abstracts

Hyalinizing trabecular tumor is an uncommon, controversial lesion of thyroid gland. Hyalinizing trabecular neoplasm share similarities with medullary thyroid carcinomas (MTC) and exhibit nuclear features resembling papillary thyroid carcinoma (PTC). However, the clinical behaviour unclear. We aimed to present a rare case of hyalinizing trabecular tumor of thyroid gland and ten-year follow up. A 54-year-old woman who was being followed up because of multinodular goiter on exami...

Aim: BRAF is one of the serine threonin kinases that activates mitogen activated protein kinase (MAPK) signal pathway.The aim of this study is to evaluatethe relationship between extrathyroidal extension (ETE) and BRAFV600E mutation in the subjects with papillary thyroid cancer.Materials and methods: Clinical and laboratory data of 455 patients, who had been followed-up in our clinic between the years 2010 and 2015 for PTC, were evaluated. The relationsh...

Aim: ATA guideline recommends complementary thyroidectomy after thyroid lobectomy in case of tumor diameter>1 cm, in the presence of metastatic tumor, invasion, history of radiation therapy, familial history of thyroid cancer, multifocal or agressive variant tumor. In this study, we aimed to evaluate the relationship between the necessity of complementary thyroidectomy and post-surgery clinical, radiologic and histopathologic results in the patients who underwent complemen...

Introduction: Co-occurence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same patient is unusual. We report a case with this rare event.Case: A 39 year old woman was presented with cough and shortness of breath. She had no prior history of radiation exposure, cigarette or alcohol consumption and no family history of thyroid cancer. On physical examination, a 3x5 cm thyroid nodule was palpated in the middle portion of thyroid gland...

Resistance to thyroid hormone (RTH) is a genetic disease characterized by a reduced target tissue responsiveness to thyroid hormones and increased or normal TSH level despite elevated levels of thyroid hormones. This condition is mainly caused by mutations of thyroid hormone receptor beta (THRB) gene. The role of THRB mutation in carcinogenesis is still unclear. In here, we report a case of papillary thyroid carcinoma (PTC) with RTH, with a past medical history of subtotal thy...

Ectopic thyroid tissue is the localization of thyroid tissue at any place other than the normal localization of the thyroid during the migration of embryonic period. Concurrent normal thyroid tissue may accompany. It usually is seen in women and in the midline. Very rarely thyroid carcinoma can develop. Treatment is like normal thyroid carcinomas, suggesting simultaneous thyroidectomy if accompanied by normal thyroid tissue. A 42-year-old female patient presented with complain...

Occurance of papiller carcinoma with foliculer thyroid carcinoma is a rare situation. We report a 49-year-old male with asymptomatic goiter. The first biopsy from the right tyroid lobe from a 6×6×4 cm iso-hypoechogen heterogeneous nodule showed bening, hurthe cell and thyrocyte rich cytology. Two months later the patient went through right lobectomy which patology defined as 4.3 cm minimal invasive follicular carcinoma. Two months after right thyroidectomy, a second ...

Radioactive iodine (RAI) treatment has been used in the treatment of differentiated thyroid cancer (DTC) since 1946. RAI treatment is recently used as adjuvant treatment for ablation of residual tissue following thyroidectomy and in the treatment of metastases of thyroid cancer. Some acute (nausea, vomiting, ageusia, salivary gland swelling and pain) and long-term side effects (sialadenitis, pulmonary fibrosis, second primary malignancies) may be observed following RAI treatme...

Anaplastic thyroid carcinoma (ATC) is the most aggressive and lethal thyroid malignancy. The median survival time following diagnosis is typically 6 months or less. β2 microglobulin (β2-MG) is a component of MHC class I molecules, which exists in all nucleated cells except red blood cells and placental trophoblast cells. Levels of beta-2 microglobulin can be elevated in multiple myeloma, lymphoma and amyloidosis. In few studies on anaplastic thyroid cancer, β2-M...

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal human malignancies. The median survival time following diagnosis is typically 6 months or less. Spontaneous thyroid haemorrhage may occur following an increase in venous pressure after Valsalva manoeuvre, hemodialysis session along with the use of heparin, trauma and in the patients with hypertension, especially in those with coagulopathy. Intrathyroidal hemorrhage may develop from a previous silent le...